Below is a list of funding opportunities (CHTF, NIA, and other sources) that may be of interest to Center for Health Trends and Forecasts (CHTF) members. Please note that the availability and eligibility for funding opportunities vary, so please read the entire announcement for complete details.
This Funding Opportunity Announcement (FOA) encourages applications to NIA's Small Business Technology Transfer Research (STTR) program to conduct research leading to the development of innovative products and/or services that may advance progress in preventing and treating Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD) and/or caring for and treating AD/ADRD patients.
This Funding Opportunity Announcement (FOA) encourages research grant applications focused on palliative care in geriatric populations. This FOA covers studies in a variety of settings including hospitals (and specific sites within hospitals including specialty medical or surgical wards, intensive care units, and emergency departments), post-acute care settings, outpatient clinics and doctors’ offices, patients’ homes and other residential settings, assisted living facilities, nursing homes, hospices, and other healthcare or community settings. This FOA encourages both prospective studies and analyses of existing datasets, health and medical records, claims data, or other sources. Leveraging ongoing cohorts, intervention studies, networks, data and specimen repositories, and other existing research resources and infrastructure are encouraged. Study designs may include observational approaches, quasi-experimental designs, and interventional studies.
This opportunity supports health services research projects; projects be related to AHRQ’s mission to produce evidence to make health care safer, higher quality, more accessible, equitable and affordable, and to work with HHS and other partners to make sure that the evidence is understood and used. Specific areas of priority include: improving health care quality by accelerating implementation of Patient Centered Outcomes Research; making health care safer; increasing accessibility by evaluating expansions of insurance coverage; improving health care affordability, efficiency and cost transparency.
This funding opportunity announcement (FOA) invites applications for basic research to better characterize the affective, cognitive, social, and motivational parameters of impaired and intact decision making in both normal aging and Alzheimer's disease (AD). Research is sought that will characterize the extent to which basic behavioral and neural processes involved in decision-making are differentially impacted in normal aging and AD, investigate the influence of social factors on decision-making, and investigate the decision-making factors that render older adults (with or without cognitive impairment) vulnerable to financial exploitation and other forms of mistreatment and abuse.
The FOA also invites applications to apply basic research on the processes involved in decision-making to the design of decision-supportive interventions for midlife and older adults with and without AD. Specific opportunities include the development of decision-supportive interventions to leverage cognitive, emotional and motivational strengths of these populations; tools to assess decisional capacity; strategies for simplifying choices and offering better defaults; and the promotion of timely adoption of optimal delegation practices (e.g., power of attorney, living wells, etc.).
This Funding Opportunity Announcement (FOA) invites applications that focus on clarifying the relationship between delirium and Alzheimer's disease and related dementias (ADRD). Specifically sought is research focusing on understanding why persons with ADRD are at increased risk to develop delirium, often with a worse prognosis compared to those without antecedent ADRD, and why patients who experience delirium are at higher risk to develop subsequent short- and/or long-term mild cognitive impairment or ADRD, often with an accelerated rate of cognitive decline compared to those without preceding delirium. Relevant research projects may focus on, but are not limited to, those that A) provide insight into possible common, sequential, causative, contributory and/or synergistic pathways underlying both ADRD and delirium, B) elucidate mechanisms that lead to the development of delirium against the background of aging and/or neurodegeneration, with particular emphasis on use of appropriate animal models, C) identify risk factors for the onset and/or progression of delirium in those with ADRD and vice versa, D) diagnose and assess one condition in the setting of the other, E) identify putative phenotypes of patients with co-existing ADRD and delirium, or F) test pharmacologic and/or non-pharmacologic strategies to prevent, treat, or reduce the impact of delirium in patients with ADRD and vice versa. Research supported by this FOA is intended to provide mechanistic insight to improve risk assessment, diagnosis, phenotyping, prevention, and management approaches for both delirium and ADRD.
The purpose of this funding opportunity announcement (FOA) is to provide infrastructure support to advance development of operational definitions and approaches for the study of the concepts of cognitive reserve and resilience to Alzheimer's disease and related dementias (ADRD) and age-related cognitive decline. The infrastructure support will facilitate a collaborative research network through meetings, conferences, small-scale pilots, and dissemination activities to foster development and champion use of state-of-the-art definitions, uniform nomenclature, and validated approaches that will be key to the advancement of research on maintenance of brain and cognitive health and treatment and/or prevention of ADRD.
This FOA allows for applications that propose large-scale, complex research projects with multiple highly integrated components focused on a common research question relevant to aging. Such projects will likely involve an integrated multidisciplinary team of investigators within a single institution or a consortium of institutions.
The purpose of this Small Business Technology Transfer Research (STTR) FOA is to encourage small businesses and their research partners to develop assistive robotics and related technology that would enhance health and reduce illness and disability in older Americans suffering from Alzheimer's Disease (AD), AD-related dementias (ADRD), and other comorbidities. In addition, this FOA encourages small businesses and their research partners to develop assistive robotics addressing the needs and conditions of caregivers to older Americans suffering from AD and ADRD.
This Funding Opportunity Announcement (FOA) encourages investigators to submit research grant applications that will identify, develop, test, evaluate and/or refine strategies to disseminate and implement evidence-based practices (e.g. behavioral interventions; prevention, early detection, diagnostic, treatment and disease management interventions; quality improvement programs) into public health, clinical practice, and community settings. In addition, studies to advance dissemination and implementation research methods and measures are encouraged.
This opportunity invites applications proposing to study health disparities in Alzheimer’s disease (AD) and related disorders. Health disparities research related to AD should include the study of biological, behavioral, sociocultural and environmental factors that influence population level health differences. Research approaches of interest include 1) improving recruitment and retention of populations underrepresented in AD research, 2) identifying priority factors or locating pathways and mechanisms that create and sustain AD health disparities, 3) addressing the challenges faced by informal/family caregivers from diverse racial, ethnic and socioeconomic backgrounds that are associated with the growing population of individuals with Alzheimer’s Disease, and 4) understanding the disparities in access to and utilization of formal long-term supports and services for those with dementia.
This funding opportunity announcement (FOA) invites studies employing secondary analysis of existing cohorts, data sets and biorepositories to explore clinically related issues on aging changes influencing health across the lifespan, including diseases and disabilities in older persons. Use of cohorts that are linked to electronic health record systems and/or Centers for Medicare and Medicaid Services (CMS) administrative data are especially welcome. This FOA will support exploratory analysis of innovative hypotheses in clinical aging research and/or to inform design of future epidemiologic or human intervention studies. Costs related to data harmonization, archival activities and/or assay refinement may be included in the budget, as long as they are pertinent to the specific aims of the proposed project.
The R21 activity code is intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects of in areas of interest to NIH IC’s. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.
To conduct collaborative research projects between U.S. and low- and middle-income country (LMIC) scientists on brain and other nervous system function and disorders throughout life. Scientists in upper middle income countries (UMICs) are eligible to partner directly with scientists at other LMIC institutions. The collaborative research programs are expected to contribute to the long-term goals of building sustainable research capacity in LMICs to address nervous system development, function and impairment throughout life and to lead to diagnostics, prevention, treatment and implementation strategies. Applicants are especially encouraged to propose research on co-morbidities and conditions that affect nervous system function at different life stages, as well as across the lifespan.
This opportunity invites applications proposing to study health disparities in Alzheimer’s disease (AD) and related disorders. Health-disparities research related to AD should include the study of biological, behavioral, sociocultural, and environmental factors that influence population level health differences. Research approaches of interest include 1) improving recruitment and retention of populations underrepresented in AD research, 2) identifying priority factors or locating pathways and mechanisms that create and sustain AD health disparities, 3) addressing the challenges faced by informal/family caregivers from diverse racial, ethnic and socioeconomic backgrounds that are associated with the growing population of individuals with Alzheimer’s Disease, and 4) understanding the disparities in access to and utilization of formal long-term supports and services for those with dementia.
This FOA invites applications that address clinical and translational research gaps in the study of end-of-life care needs in order to improve quality of life at the end of life of people with Alzheimer’s disease and related dementias (ADRD) and their families. Research that either employs (a) secondary analysis of existing data from longitudinal cohort studies or from administrative records or (b) primary data collection for Stage I behavioral intervention development is particularly encouraged.
This FOA invites applications that will combine multiple cohorts in order to improve statistical power and clarify risk and protective factors for Alzheimer’s disease and related dementias (AD/ADRD).
This opportunity encourages investigator-initiated applications addressing the epidemiology of Alzheimer’s disease (AD) as well as protective factors for cognitive health and resilience. All projects in cognitive epidemiology and genetics/genomics relevant to AD are welcome. NIA especially encourages projects or revisions to projects that propose: augmenting existing longitudinal cohort studies; enabling precision medicine for AD; enhancing the power of multi-ethnic cohort studies; exploring trends in the risk of AD and their explanation via putative risk and protective factors; collecting and sequencing DNA samples from well-characterized cases and controls; electronic archiving of cohort studies; harmonizing complex data sets relevant to AD; and harmonizing dementia assessment to enhance cross-national comparisons.
Despite significant scientific advancements made in substance use disorder research over the last century, the causes and consequences of drug use in later life remain poorly understood. The intent of this funding opportunity announcement is to support innovative research that examines aspects of marijuana and prescription opioid and benzodiazepine use in adults aged 50 and older. This FOA encourages research that examines the determinants of these types of drug use and/or characterizes the resulting neurobiological alterations, associated behaviors, and public health consequences. This initiative will focus on two distinct populations of older adults: individuals with earlier onset of drug use who are now entering this stage of adult development or individuals who initiate drug use after the age of 50. Applications are encouraged to utilize broad methodologies ranging from basic science, clinical, and epidemiological approaches. The insights gleaned from this initiative are critical to our understanding of the determinants of drug use in later life, as well as its consequences in the aging brain and on behavior. This knowledge may have the potential to identify risk factors and to guide clinical practices in older populations.
The purpose of this Funding Opportunity Announcement (FOA) is to promote research to understand the underlying mechanisms of sleep deficiencies among health disparity populations and how sleep deficiencies may lead to disparities in health outcomes.
The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and “protected time” for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research. By the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence.
The purpose of this K01 is to provide support and “protected time” for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Award covers both research and professional development. By the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence.
This FOA encourages applications that propose to conduct secondary data analyses utilizing existing database resources. Applications may be related to, but must be distinct from, the specific aims of the original data collection. The NEI supports an extensive portfolio of clinical trials and large-scale epidemiologic research projects, wherein numerous data collection activities are required to meet each project's specific aims. The resultant wealth of data generated by these studies often provides unique, cost-effective opportunities to investigate additional research questions or develop new analytical approaches secondary to a project's originally-intended purpose. The R21 may be used to develop new statistical methodologies or to test hypotheses using existing data.
The National Institute on Aging invites the submission of investigator-initiated program project (P01) applications. The applications should address scientific areas relevant to the NIA mission. Each application submitted to this FOA must include at least three related research projects that share a common central theme, focus, and/overall objective and an administrative core to lead the project.
This Funding Opportunity Announcement (FOA) invites applications for basic and translational research on caregiving for individuals with Alzheimer’s disease (AD), at the individual, family, community, and population level. The scope of this funding opportunity includes support for applications that propose the following: early-stage development of interventions to reduce caregiver burden and improve patient outcomes across various settings; population- and community-based research on the scope and impact of AD caregiving; improved characterization of informal and formal caregiving and the burden of caregiving across the full spectrum of the disease, including differences among socioeconomic, racial/ethnic and geographic sub-populations; and research addressing the unique challenges related to the provision of advanced AD care, including disparities in access to care.
The Research Project Grant (R01) supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on descriptions of their programs.
The RRF advances new directions in research particularly in disciplines for which external funding opportunities are minimal, for faculty who are junior in rank, and/or in cases where funding may provide unique opportunities to increase applicants’ competitiveness for subsequent funding. Proposals must demonstrate a high probability of generating important new creative activities or scholarly understandings, new scholarly materials or resources, significant data or information, or essential instrumentation resources that are likely to significantly advance the reputation of the university, lead to external funding, or lead to developing a new technology. RRF proposals must support faculty development; this fund is not intended to support independent research projects undertaken by students.
The purpose of the Kirschstein-NRSA postdoctoral fellowship (F32) award is to enhance the research training of promising postdoctoral candidates who have the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of the participating NIH Institutes and Centers. By the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence.
The purpose of the Kirschstein-NRSA predoctoral fellowship (F31) award is to enable promising predoctoral students to obtain individualized, mentored research training from outstanding faculty sponsors while conducting dissertation research in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers. By the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence.
This funding opportunity announcement (FOA) invites applications employing secondary analysis of existing data sets or stored biospecimens, to address clinically related issues on aging changes influencing health across the lifespan, and/or on diseases and disabilities in older persons. Use of cohorts that are linked to electronic health record systems and/or Centers for Medicare and Medicaid Services (CMS) administrative data are especially welcome. This FOA will support activities addressing specific hypotheses in clinical aging research and/or to inform the design and implementation of future epidemiologic or human intervention studies, or current geriatric practice in maintenance of health, management of disease, and prevention of disability. Existing data sets may also be used to develop and test new statistical analytical approaches. Costs for archiving of data to be made publicly available and those associated with data harmonization or assay refinement/validation may be included in the budget, as long as these activities are pertinent to the proposed secondary analyses.
The National Institutes of Health (NIH) Investigator-Initiated Small Research Grant (R03) funding opportunity supports small research projects that can be carried out in a short period of time with limited resources. The R03 activity code supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.
The involvement of small businesses in translational aging research could substantially hasten the pace at which scientific advances are transformed into commercial products to improve or maintain the health and functional independence of older adults. Therefore, this funding opportunity announcement (FOA) is intended to encourage a greater involvement by small businesses through the SBIR mechanism in transforming scientific advances in aging research into novel devices, products, health care practices and programs that will benefit the lives of older adults.
For the purposes of this FOA, T1 translational research on aging is defined as the application of basic and clinical biomedical or basic behavioral and social research findings towards the development of new strategies for prevention and treatment of age-related pathologies. T1 translational research approaches could include the development of new research tools or improving existing technologies to diagnose, prevent or treat age-related conditions, functional decline and disability.