The Local Burden of Disease project at IHME aims to produce estimates of health outcomes and related measures that cover entire continents, but to do so at a granular, local resolution. Such estimates will allow decision-makers to target resources and health interventions precisely, so that health policy decisions can be tailored for local areas rather than entire countries. Combining local detail with broad coverage – producing estimates for primary (e.g., state, province) and secondary (e.g., district, municipality) administrative subdivisions across entire continents and, eventually, the world – would give health officials everywhere the tools to make locally informed decisions and, in the process, help all people live longer, healthier lives.