The Global Burden of Disease (GBD) approach endeavors to measure disability and death from a multitude of causes worldwide. It has grown over the past two decades years into an international consortium of more than 1,000 researchers, and its estimates are being updated annually.
The GBD enterprise dates to the early 1990s, when the World Bank commissioned the original GBD study and featured it in the landmark World Development Report 1993: Investing in Health. Co-authored by Dr. Christopher Murray, who went on to become Director of IHME, this GBD study served as the most comprehensive effort up to that point to systematically measure the world’s health problems, generating estimates for 107 diseases and 483 sequelae (nonfatal health consequences related to a disease). It covered eight regions and five age groups with estimates through 1990.
The GBD 1990 study had a profound impact on health policy and agenda-setting throughout the world, especially as it brought global attention to otherwise hidden or neglected health challenges, such as mental illness and the burden of road injuries. Academic papers from GBD 1990 have been cited more than 11,000 times since they were published.
GBD work was institutionalized at the World Health Organization (WHO), and the organization continued to update GBD findings.
In 1998, the WHO created a Disease Burden Unit, which generated GBD estimates for 2000, 2001, and 2002, publishing the estimates in WHO’s annual World Health Reports. In 2008, WHO updated the GBD estimates for 2004. By the time of the GBD 2004 study, the causes of death and disability being studied had grown to 136.
The next comprehensive GBD update, the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) published new estimates for the complete time series from 1990 to 2010 and an explanation of its methods in The Lancet in December 2012 in seven papers, commentaries, and accompanying comprehensive web appendices totaling more than 2,300 pages.
While the earlier work had been conducted mainly by researchers at Harvard and the World Health Organization, GBD 2010 brought together a community of nearly 500 experts from around the world in epidemiology, statistics, and other disciplines.
Funded by the Bill & Melinda Gates Foundation, GBD 2010 significantly broadened the scope of previous versions of GBD. Using improved methods for estimating disability weights, GBD 2010 produced estimates for 291 diseases and injuries, 67 risk factors, 1,160 sequelae, 21 regions, 20 age groups, and 187 countries.
The policy report The Global Burden of Disease: Generating Evidence, Guiding Policy summarizes the GBD 2010 methods and results.
In 2013, the World Bank and GBD researchers renewed the fruitful collaboration they began two decades earlier by launching a series of six regional reports based on findings from GBD 2010.
With IHME as the coordinating center for an international network of GBD contributors, the entire time series of GBD estimates are being updated annually to provide policymakers, donors, and other decision-makers with the most timely and useful picture of population health. The first update, GBD 2013, expands the methodology, datasets, and tools used in GBD 2010 and presents estimates of all-cause mortality, deaths by cause, years of life lost, years lived with disability, and disability-adjusted life years by country, age, and sex. GBD 2013 produced estimates for 323 diseases and injuries, 67 risk factors, and 1,500 sequelae for 188 countries. It reflects the work of more than 1,000 researchers in more than 100 countries. Beginning in 2014, GBD 2013 findings have been published in a series of papers on smoking; maternal mortality; child mortality; overweight and obesity; HIV/AIDS, malaria, and tuberculosis; and causes of death.
Further papers on nonfatal outcomes, disability-adjusted life years, and risk factors are in the publication process. GBD collaborators are now working on the next update, which will show results through 2015.