The articles of this issue of the Brazilian Journal of Epidemiology are the result of efforts to estimate and analyze the burden of disease in Brazil and in its states. Among others, health metrics such as potential years of life lost (YLL) and years of healthy life lost (disability-adjusted life year - DALY) were used.

The articles present the methodology of the GBD study in Portuguese, analyze the quality of available information on mortality, develop analyses on important causes of death in Brazil, morbidity, disability/limitations, risk factors, and loss of health due to various causes.

The release of this supplement does not conclude the study. This publication aims at disseminating the concepts and methods of GBD in Brazil, to welcome criticism, to deepen the analyses and to expand the network of collaborators in the country, in an ongoing process of improvement.