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Publication date: 
January 1, 2013

Abstract

Measuring the survival of human immunodeficiency virus–infected adult patients enrolled in antiretroviral therapy (ART) programs is complicated by short observation periods and loss to follow-up. We synthesized data from treatment cohorts in sub-Saharan Africa to estimate survival over 5 years after initiation of ART.

Methods

We used data on retention, mortality, and loss to follow-up from 34 cohorts, including a total of 102 306 adult patients from 18 sub-Saharan African countries. These data were augmented by data from 13 sub-Saharan African studies tracking death rates among adult patients who were lost to follow-up (LTFU). We used a Poisson regression model to estimate survival over time, incorporating predicted mortality among LTFU patients.

Results

Across studies, the median CD4+ cell count at ART initiation was 104 cells/mm3, 65% of patients were female, and the median age was 37 years. Survival at 1 year and 5 years were estimated to be 0.87 (95% confidence interval [CI], 0.72–0.94) and 0.70 (95% CI, 0.36–0.86), respectively, after adjustment for loss to follow-up. The life-years gained by a patient during the 5-year period after starting ART were estimated at 2.1 (95% CI, 1.6–2.3) in the adjusted model, compared with 1.7 (95% CI, 1.1–2.0) if there was 100% mortality among LTFU patients and with 2.4 (1.7–2.7) if there was 0% mortality among LTFU patients.

Conclusions

Accounting for loss to follow-up produces substantial changes in the estimated life-years gained during the first 5 years of ART receipt.
Citation: 

Verguet S, Lim SS, Murray CJL, Gakidou E, Salomon J. Incorporating loss to follow-up in estimates of survival among HIV-infected individuals in sub-Saharan Africa enrolled in antiretroviral therapy programs. Journal of Infectious Diseases. 2013;207:72-79.