Summary Acute hepatitis C resulted in 253 000 global DALYs (95% UI 145 000–375 000) in 2019 and was responsible for 5·8% (3·4–8·8) of acute hepatitis DALYs.
Definition Hepatitis C is a viral infection of the liver. It is transmitted through injecting needles and during medical procedures.
Total sources | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Incidence | 0 | |||||||||||
Prevalence | 300 | |||||||||||
Remission | 0 | |||||||||||
Causes of death | 1841 | |||||||||||
Other | 32 | |||||||||||
Table 1:
Total sources used in GBD 2019 estimation
What is new in GBD 2019?
- •Adjustment for seroprevalence data among blood donors was estimated in MR-BRT using 35 sources; 52 datapoints on pregnant women were dropped because of lack of overlapping data to inform an adjustment.
- •Analysis conducted in MR-BRT using 42 studies that reported on the prevalence of anti-HCV antibody and HCV-RNA produced a pooled estimate of proportion viremic among the seropositive individuals. This was used to correct outputs of our model of anti-HCV seropositivity to estimate viremia, instead of the proportion based on a single study used in previous rounds of GBD.
- •Acute hepatitis C mortality was modelled in CODEm rather than the natural history model used in GBD 2017, which had the effect of increasing estimates. This allowed us to drop the assumption that case fatality ratios estimated from hospital inpatient data can be applied to all symptomatic cases of acute hepatitis C occurring in the community.
Prevalence
|
Incidence
|
Deaths
|
YLLs
|
YLDs
|
DALYs
|
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---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases
(millions) |
Rate (per 100 000)
|
Cases
(millions) |
Rate (per 100 000)
|
Deaths
(millions) |
Rate (per 100 000)
|
YLLs
(millions) |
Rate (per 100 000)
|
YLDs
(millions) |
Rate (per 100 000)
|
DALYs
(millions) |
Rate (per 100 000)
|
|
2019 | ||||||||||||
Both Sexes | 0·636 (0·561 to 0·737) |
8·5 (7·5 to 9·9) |
5·51 (4·86 to 6·39) |
73·9 (65·3 to 85·6) |
0·00548 (0·00331 to 0·00844) |
0·1 (0·0 to 0·1) |
0·244 (0·136 to 0·367) |
3·2 (1·7 to 4·8) |
0·00891 (0·00426 to 0·0175) |
0·1 (0·1 to 0·2) |
0·253 (0·145 to 0·375) |
3·3 (1·9 to 4·9) |
Females | 0·318 (0·280 to 0·368) |
8·6 (7·6 to 10·0) |
2·76 (2·43 to 3·19) |
74·2 (65·4 to 86·5) |
0·00313 (0·00176 to 0·00502) |
0·1 (0·0 to 0·1) |
0·137 (0·0698 to 0·229) |
3·6 (1·8 to 6·0) |
0·00446 (0·00214 to 0·00881) |
0·1 (0·1 to 0·2) |
0·142 (0·0733 to 0·232) |
3·7 (1·9 to 6·1) |
Males | 0·318 (0·280 to 0·367) |
8·5 (7·5 to 9·8) |
2·75 (2·43 to 3·18) |
73·7 (65·2 to 84·8) |
0·00235 (0·00132 to 0·00447) |
0·1 (0·0 to 0·1) |
0·107 (0·0569 to 0·201) |
2·8 (1·5 to 5·2) |
0·00445 (0·00212 to 0·00880) |
0·1 (0·1 to 0·2) |
0·112 (0·0608 to 0·209) |
2·9 (1·6 to 5·4) |
Percentage change 2010-19 | ||||||||||||
Both Sexes | 11·5% (9·7 to 13·7) |
1·2% (0·0 to 2·6) |
11·5% (9·7 to 13·7) |
1·2% (0·0 to 2·6) |
–20·8% (–36·9 to 2·6) |
–32·5% (–46·2 to –12·3) |
–30·4% (–48·2 to –7·7) |
–37·8% (–53·7 to –17·6) |
11·6% (8·3 to 14·8) |
1·3% (–1·4 to 4·0) |
–29·4% (–46·9 to –7·4) |
–36·9% (–52·7 to –17·4) |
Females | 12·9% (10·7 to 15·4) |
2·1% (0·6 to 3·6) |
12·9% (10·7 to 15·4) |
2·1% (0·6 to 3·6) |
–25·4% (–45·1 to 3·8) |
–36·9% (–53·6 to –12·1) |
–35·2% (–54·6 to –7·3) |
–42·5% (–59·9 to –17·8) |
12·9% (8·7 to 16·9) |
2·1% (–1·6 to 5·9) |
–34·3% (–53·7 to –7·0) |
–41·7% (–59·1 to –17·3) |
Males | 10·2% (8·3 to 12·3) |
0·3% (–1·1 to 1·7) |
10·2% (8·3 to 12·3) |
0·3% (–1·1 to 1·7) |
–13·6% (–44·8 to 22·8) |
–25·7% (–52·0 to 4·8) |
–23·1% (–52·5 to 17·3) |
–30·8% (–57·1 to 3·6) |
10·4% (6·4 to 14·2) |
0·4% (–2·8 to 3·5) |
–22·2% (–51·0 to 17·1) |
–29·9% (–55·9 to 3·4) |
Numbers in parentheses are 95% uncertainty intervals. |
Table 2:
Global prevalence, incidence, deaths, YLLs, YLDs, and DALYs in counts and age-standardised rates for both sexes combined, females, and males, 2019, with percentage change between 2010 and 2019
Deaths | YLLs | YLDs | DALYs | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
1990 | 179th | 170th | 266th | 234th | ||||||||
2010 | 186th | 184th | 266th | 258th | ||||||||
2019 | 188th | 191st | 266th | 265th | ||||||||
Table 3:
Rank among most detailed causes for global deaths, YLLs, YLDs, and DALYs in 1990, 2010, and 2019, for both sexes combined

Figure 1:
Composition of DALYs by YLLs and constituent sequelae YLDs for both sexes combined, 2019

Figure 2:
Percentage of DALYs attributable to top risk factors for both sexes combined, 2019


Figure 3:
Age-standardised DALY rates for each location by SDI, both sexes combined, 2019

Figure 4:
Composition of DALYs by YLLs and YLDs, age group, and sex, 2019


Figure 5:
Age-standardised DALY rates (per 100 000) by location, both sexes combined, 2019