We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to estimate the burden of disease attributable to mental and substance use disorders in terms of disability-adjusted life years (DALYs), years of life lost to premature mortality (YLLs), and years lived with disability (YLDs).
Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.
We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) to estimate the global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990—2010.
Previous estimates of mortality in Iraq attributable to the 2003 invasion have been heterogeneous and controversial, and none were produced after 2006. The purpose of this research was to estimate direct and indirect deaths attributable to the war in Iraq between 2003 and 2011.
Previous studies of anemia epidemiology have been geographically limited with little detail about severity or etiology. Using publicly available data, we estimated mild, moderate and severe anemia from 1990 to 2010 for 187 countries, both sexes, and 20 age groups. We then performed cause-specific attribution to 17 conditions using data and resources from the Global Burden of Diseases, Injuries and Risk Factors (GBD) 2010 Study.
Rates of neonatal and maternal mortality are high in Ghana. In-facility delivery and other maternal services could reduce this burden, yet utilization rates of key maternal services are relatively low, especially in rural areas. We tested a theoretical implication that travel time negatively affects the use of in-facility delivery and other maternal services.
No systematic attempts have been made to estimate the global and regional prevalence of amphetamine, cannabis, cocaine, and opioid dependence, and quantify their burden. We aimed to assess the prevalence and burden of drug dependence, as measured in years of life lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life years (DALYs).
Over the last 30 years, HIV/AIDS has emerged as a major global health challenge. Globally, the trend is that non-communicable diseases and injuries are accounting for a larger share of disease burden, but HIV/AIDS is a notable exception. Maintaining and expanding the response to the epidemic will require assessment of its magnitude and impact at the country level. It is also critical to examine the HIV/AIDS epidemic in the context of other health problems to clearly understand its impact and effectively allocate resources.
In 2012, data from GBD 2010 were published, providing results for 1990, 2005, and 2010. Hundreds of collaborators reported summary results for the world and 21 epidemiologic regions, covering 291 diseases and injuries, 1,160 sequelae of these causes, and mortality and burden attributable to 67 risk factors. GBD 2010 addressed a number of major limitations to previous analyses, including strengthening the statistical methods used for estimation and using disability weights derived from surveys of the general population. Metrics produced include leading causes of death, years of life lost, years lived with disability, and disability-adjusted life years (DALYs), which are the years of healthy life lost by a person due to death or disability.
Under-5 mortality, the probability of death before age 5, is an important indicator of child health in a population. Because estimates of under-5 mortality are often derived from birth history data from censuses or surveys, it is important to know how accurate these estimates are, particularly estimates derived from small samples of women. Researchers aimed to assess the magnitude and direction of error for estimates derived from birth histories using several analysis methods.
HIV prevalence over time is a critical metric for understanding the effectiveness of programs aiming to prevent HIV. Prevalence is often measured using surveillance of clinic patients, which can lead to selection bias: clinics located in areas of high HIV prevalence are often the first to be monitored by the surveillance systems, distorting the estimated HIV prevalence based on clinic data. To help understand the impact of selection bias on the estimation of HIV prevalence trends, researchers compared the efficacy of two approaches for handling selection bias.
The United States spends more than any other country on health care, but US life expectancy at birth ranked 40th for males and 39th for females globally in 2010. To help understand this poor national performance, as well as the large disparities seen in life expectancy across communities, researchers estimated age-specific mortality rates for males and females by US county from 1985 to 2010.
Obesity and lack of physical activity are associated with several chronic conditions, such as heart disease and diabetes, increased health care costs, and premature death. Since different local governments have pursued different approaches to address both risks, levels of obesity and physical activity are likely to vary substantially across counties. To understand local trends in physical activity and obesity that would help identify successful and less successful strategies, researchers examined county-level changes in physical activity and obesity between 2001 and 2011.
To better inform national health policy, it is critical to understand the major health problems in the United States and how they are changing over time. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), researchers compared health outcomes in the US with those of the 34 countries in the Organization for Economic Co-operation and Development (OECD).
Violence against women is a phenomenon that persists in all countries. However, documenting the magnitude of violence against women and producing reliable comparative data to guide policy and monitor progress has been difficult.
An estimated 6% of global infant deaths are attributable to congenital anomalies, of which 92% occur in low-income and middle-income countries (LMICs). Some of the conditions can be treated by specialized surgical procedures that have been frequently provided through established vertical programs. This study aims to quantify the burden of congenital anomalies in LMICs that could be averted should the surgical programs be scaled up to 100% coverage.
China has seen striking declines in child mortality and an increase in life expectancy due to rapid demographic and epidemiological changes in the past few decades, yet dietary risks, tobacco use, and the rise of non-communicable diseases such as cancer pose risks to continued improvements in health.
Our study is the first to quantify the effect of these biases. We analyse multiple surveys per country or territory and show how the estimated share of the household expenditure devoted to health (i.e. health expenditure share) would have varied if survey instruments with different characteristics had been employed. Our contribution makes it possible for analysts to compare health expenditure share estimates across surveys.
The Global Burden of Disease (GBD) 2010 study produced comparable estimates of the burden of 291 diseases and injuries in 1990, 2005, and 2010. This article reports on the global burden of untreated caries, severe periodontitis, and severe tooth loss in 2010 and compares those figures with new estimates for 1990.
Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. Here we undertake an exhaustive assembly of known records of dengue occurrence worldwide, and use a formal modeling framework to map the global distribution of dengue risk. We then pair the resulting risk map with detailed longitudinal information from dengue cohort studies and population surfaces to infer the public health burden of dengue in 2010.
Hypertension is an important and modifiable risk factor for cardiovascular disease and mortality. We estimate trends in prevalence, awareness, treatment, and control of hypertension in US counties using data from the National Health and Nutrition Examination Survey (NHANES) in five two-year waves from 1999–2008 including 26,349 adults aged 30 years and older and from the Behavioral Risk Factor Surveillance System (BRFSS) from 1997–2009 including 1,283,722 adults aged 30 years and older.
It is perhaps surprising to state that we have an extremely poor knowledge of the global distribution of the vast majority of infectious diseases. Here we argue that this information gulf has serious implications for global public health surveillance and that too little attention is given to spatial epidemiology in international preparedness planning.
The United Kingdom has provided universal health care and public health programming for more than six decades. To guide future policymaking in the UK, it is important to analyze trends in population health over time. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), researchers examined three critical questions: what are the patterns of health loss in the UK, what are the leading preventable risks that explain some of those patterns, and how do UK outcomes compare to a set of comparable countries in the European Union (EU) and elsewhere in 1990 and 2010.
These findings suggest that greater reductions in malaria morbidity and health gains for children may be achieved with ITNs and IRS combined beyond the protection offered by IRS or ITNs alone.
The primary aim of this review was to evaluate the state of knowledge of the geographical distribution of all infectious diseases of clinical significance to humans.