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GRAM Project Deliverables and Scope


State of evidence on AMR

  • Relatively poor information about geographical distribution and burden of AMR
  • Multiple public and private sources of data – often not collated at the national and international levels
  • Data collection often with little information on individual patients
  • Fundamental issues of selection bias on who gets into hospital-based lab data systems
  • Protocols for diagnostic methods and data collection not yet standardized

Project deliverables

  1. Gather and assemble global data on 17 bacteria-antibacterial drug combinations
  2. Develop methods to generate AMR/DRI burden estimates for the selected pathogen-drug combinations of international concern
  3. Provide results through a compelling interface for data visualization

Project scope and approach

We will prioritize estimating burden for 17 “bug-drug” combinations of international public health concern and priority for the WHO member states, as well as the Bill & Melinda Gates Foundation:

Bacteria Antibacterial drug(s)
Escherichia coli Third-generation cephalosporins, fluoroquinolones
Shigella Fluoroquinolones
Klebsiella pneumoniae Third-generation cephalosporins, carbapenems
Streptococcus pneumoniae Penicillin
Staphylococcus pneumoniae Methicillin
Salmonella Typhi and Paratyphi Fluoroquinolones, chloramphenicol
Non-typhoidal Salmonellae Fluoroquinolones
Neisseria gonorrhoeae Third-generation cephalosporins
Mycobacterium tuberculosis First-line - isoniazid, rifampicin; Second-line - fluoroquinolones, amikacin, capreomycin, kanamycin

 


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Institute for Health Metrics and Evaluation

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Tel: +1-206-897-2800

Fax: +1-206-897-2899

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