Summary Chronic kidney disease (CKD) was responsible for 41·5 million (95% UI 38·3–45·0) DALYs in 2019. Age-standardised DALY rates were highest in central and Andean Latin America, at 1348·1 (1203·6–1521·6) and 836·3 (704·2–981·6) per 100 000, respectively (global rate was 514·9 [474·9–558·9]).

Definition This cause incorporates death and disability due to CKD defined as an estimated glomerular filtration rate less than 60 ml/min/1.73m2 or albumin to creatinine ratio >30mg/g. This includes those with end-stage kidney disease who are on dialysis or have had a transplant.

Total sources
Incidence 1072
Prevalence 1204
Remission 0
Causes of death 3810
Other 437
Table 1: Total sources used in GBD 2019 estimation
What is new in GBD 2019?
  • •Excess mortality data were modelled in MR-BRT by age and sex as a function of HAQ Index.
  • •Adjustments for alternative CKD estimating equations were applied prior to DisMod-MR. These adjustments led to somewhat higher estimates for stage 3 estimations but little change for stages 4 and 5 CKD.
Prevalence
Incidence
Deaths
YLLs
YLDs
DALYs
Cases
(millions)
Rate (per 100 000)
Cases
(millions)
Rate (per 100 000)
Deaths
(millions)
Rate (per 100 000)
YLLs
(millions)
Rate (per 100 000)
YLDs
(millions)
Rate (per 100 000)
DALYs
(millions)
Rate (per 100 000)
2019
Both Sexes
697
(650
to 741)
8596·2
(8015·7
to 9125·3)
19·0
(17·6
to 20·5)
233·7
(216·6
to 252·3)
1·43
(1·31
to 1·52)
18·3
(16·7
to 19·5)
32·8
(30·5
to 35·0)
406·5
(377·9
to 434·1)
8·75
(6·32
to 11·5)
108·4
(78·5
to 142·6)
41·5
(38·3
to 45·0)
514·9
(474·9
to 558·9)
Females
383
(357
to 407)
9049·8
(8425·0
to 9616·1)
10·5
(9·70
to 11·3)
243·6
(225·9
to 262·7)
0·686
(0·615
to 0·742)
15·8
(14·2
to 17·1)
14·8
(13·5
to 16·1)
350·5
(318·5
to 380·6)
4·72
(3·43
to 6·18)
113·1
(81·9
to 147·7)
19·6
(17·7
to 21·5)
463·6
(419·3
to 510·0)
Males
314
(293
to 335)
8109·8
(7573·0
to 8608·0)
8·51
(7·84
to 9·23)
223·0
(206·1
to 241·2)
0·741
(0·686
to 0·802)
21·6
(19·9
to 23·3)
18·0
(16·7
to 19·6)
470·2
(435·5
to 510·9)
4·02
(2·90
to 5·34)
104·0
(75·6
to 137·1)
22·0
(20·1
to 24·0)
574·2
(527·5
to 625·3)
Percentage change 2010-19
Both Sexes
24·7%
(23·7
to 25·6)
2·8%
(2·4
to 3·2)
33·9%
(32·6
to 35·1)
5·9%
(5·2
to 6·5)
28·8%
(22·3
to 35·3)
–1·0%
(–5·8
to 3·8)
20·3%
(13·5
to 27·1)
–2·1%
(–7·6
to 3·3)
19·2%
(17·0
to 21·5)
–0·9%
(–2·5
to 0·7)
20·1%
(14·9
to 25·4)
–1·8%
(–6·0
to 2·4)
Females
24·3%
(23·3
to 25·4)
2·4%
(1·9
to 2·9)
32·2%
(30·7
to 33·6)
4·9%
(4·0
to 5·9)
30·0%
(21·9
to 38·4)
–0·2%
(–6·3
to 6·3)
21·5%
(12·7
to 30·6)
–1·5%
(–8·7
to 5·8)
19·5%
(17·1
to 22·1)
–0·3%
(–1·9
to 1·4)
21·0%
(14·5
to 27·9)
–1·2%
(–6·6
to 4·5)
Males
25·1%
(24·1
to 26·1)
3·3%
(2·9
to 3·7)
36·1%
(34·8
to 37·3)
7·2%
(6·5
to 7·9)
27·7%
(19·7
to 35·4)
–2·1%
(–7·9
to 3·3)
19·4%
(11·6
to 27·7)
–2·8%
(–8·9
to 3·7)
18·9%
(16·5
to 21·5)
–1·7%
(–3·4
to 0·2)
19·3%
(12·9
to 26·1)
–2·6%
(–7·8
to 2·7)
Numbers in parentheses are 95% uncertainty intervals.
Table 2: Global prevalence, incidence, deaths, YLLs, YLDs, and DALYs in counts and age-standardised rates for both sexes combined, females, and males, 2019, with percentage change between 2010 and 2019
Deaths YLLs YLDs DALYs
1990 19th 24th 38th 29th
2010 14th 15th 29th 19th
2019 11th 16th 26th 18th
Table 3: Rank among Level 3 causes for global deaths, YLLs, YLDs, and DALYs in 1990, 2010, and 2019, for both sexes combined
Figure 1: Composition of DALYs by constituent Level 4 causes for both sexes combined, 2019
Figure 2: Percentage of DALYs attributable to top risk factors for both sexes combined, 2019
No Legend
Figure 3: Age-standardised DALY rates for each location by SDI, both sexes combined, 2019
Figure 4: Composition of DALYs by YLLs and YLDs, age group, and sex, 2019
No Legend
Figure 5: Age-standardised DALY rates (per 100 000) by location, both sexes combined, 2019