Summary Chronic kidney disease (CKD) was responsible for 41·5 million (95% UI 38·3–45·0) DALYs in 2019. Age-standardised DALY rates were highest in central and Andean Latin America, at 1348·1 (1203·6–1521·6) and 836·3 (704·2–981·6) per 100 000, respectively (global rate was 514·9 [474·9–558·9]).
Definition This cause incorporates death and disability due to CKD defined as an estimated glomerular filtration rate less than 60 ml/min/1.73m2 or albumin to creatinine ratio >30mg/g. This includes those with end-stage kidney disease who are on dialysis or have had a transplant.
Total sources | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Incidence | 1072 | |||||||||||
Prevalence | 1204 | |||||||||||
Remission | 0 | |||||||||||
Causes of death | 3810 | |||||||||||
Other | 437 | |||||||||||
Table 1:
Total sources used in GBD 2019 estimation
What is new in GBD 2019?
- •Excess mortality data were modelled in MR-BRT by age and sex as a function of HAQ Index.
- •Adjustments for alternative CKD estimating equations were applied prior to DisMod-MR. These adjustments led to somewhat higher estimates for stage 3 estimations but little change for stages 4 and 5 CKD.
Prevalence
|
Incidence
|
Deaths
|
YLLs
|
YLDs
|
DALYs
|
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases
(millions) |
Rate (per 100 000)
|
Cases
(millions) |
Rate (per 100 000)
|
Deaths
(millions) |
Rate (per 100 000)
|
YLLs
(millions) |
Rate (per 100 000)
|
YLDs
(millions) |
Rate (per 100 000)
|
DALYs
(millions) |
Rate (per 100 000)
|
|
2019 | ||||||||||||
Both Sexes | 697 (650 to 741) |
8596·2 (8015·7 to 9125·3) |
19·0 (17·6 to 20·5) |
233·7 (216·6 to 252·3) |
1·43 (1·31 to 1·52) |
18·3 (16·7 to 19·5) |
32·8 (30·5 to 35·0) |
406·5 (377·9 to 434·1) |
8·75 (6·32 to 11·5) |
108·4 (78·5 to 142·6) |
41·5 (38·3 to 45·0) |
514·9 (474·9 to 558·9) |
Females | 383 (357 to 407) |
9049·8 (8425·0 to 9616·1) |
10·5 (9·70 to 11·3) |
243·6 (225·9 to 262·7) |
0·686 (0·615 to 0·742) |
15·8 (14·2 to 17·1) |
14·8 (13·5 to 16·1) |
350·5 (318·5 to 380·6) |
4·72 (3·43 to 6·18) |
113·1 (81·9 to 147·7) |
19·6 (17·7 to 21·5) |
463·6 (419·3 to 510·0) |
Males | 314 (293 to 335) |
8109·8 (7573·0 to 8608·0) |
8·51 (7·84 to 9·23) |
223·0 (206·1 to 241·2) |
0·741 (0·686 to 0·802) |
21·6 (19·9 to 23·3) |
18·0 (16·7 to 19·6) |
470·2 (435·5 to 510·9) |
4·02 (2·90 to 5·34) |
104·0 (75·6 to 137·1) |
22·0 (20·1 to 24·0) |
574·2 (527·5 to 625·3) |
Percentage change 2010-19 | ||||||||||||
Both Sexes | 24·7% (23·7 to 25·6) |
2·8% (2·4 to 3·2) |
33·9% (32·6 to 35·1) |
5·9% (5·2 to 6·5) |
28·8% (22·3 to 35·3) |
–1·0% (–5·8 to 3·8) |
20·3% (13·5 to 27·1) |
–2·1% (–7·6 to 3·3) |
19·2% (17·0 to 21·5) |
–0·9% (–2·5 to 0·7) |
20·1% (14·9 to 25·4) |
–1·8% (–6·0 to 2·4) |
Females | 24·3% (23·3 to 25·4) |
2·4% (1·9 to 2·9) |
32·2% (30·7 to 33·6) |
4·9% (4·0 to 5·9) |
30·0% (21·9 to 38·4) |
–0·2% (–6·3 to 6·3) |
21·5% (12·7 to 30·6) |
–1·5% (–8·7 to 5·8) |
19·5% (17·1 to 22·1) |
–0·3% (–1·9 to 1·4) |
21·0% (14·5 to 27·9) |
–1·2% (–6·6 to 4·5) |
Males | 25·1% (24·1 to 26·1) |
3·3% (2·9 to 3·7) |
36·1% (34·8 to 37·3) |
7·2% (6·5 to 7·9) |
27·7% (19·7 to 35·4) |
–2·1% (–7·9 to 3·3) |
19·4% (11·6 to 27·7) |
–2·8% (–8·9 to 3·7) |
18·9% (16·5 to 21·5) |
–1·7% (–3·4 to 0·2) |
19·3% (12·9 to 26·1) |
–2·6% (–7·8 to 2·7) |
Numbers in parentheses are 95% uncertainty intervals. |
Table 2:
Global prevalence, incidence, deaths, YLLs, YLDs, and DALYs in counts and age-standardised rates for both sexes combined, females, and males, 2019, with percentage change between 2010 and 2019
Deaths | YLLs | YLDs | DALYs | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
1990 | 19th | 24th | 38th | 29th | ||||||||
2010 | 14th | 15th | 29th | 19th | ||||||||
2019 | 11th | 16th | 26th | 18th | ||||||||
Table 3:
Rank among Level 3 causes for global deaths, YLLs, YLDs, and DALYs in 1990, 2010, and 2019, for both sexes combined

Figure 1:
Composition of DALYs by constituent Level 4 causes for both sexes combined, 2019

Figure 2:
Percentage of DALYs attributable to top risk factors for both sexes combined, 2019


Figure 3:
Age-standardised DALY rates for each location by SDI, both sexes combined, 2019

Figure 4:
Composition of DALYs by YLLs and YLDs, age group, and sex, 2019


Figure 5:
Age-standardised DALY rates (per 100 000) by location, both sexes combined, 2019