Summary Cirrhosis and other chronic liver diseases due to alcohol use resulted in 11·2 million (95% UI 9·45–13·1) global DALYs in 2019.

Definition Cirrhosis and other chronic liver diseases due to alcohol use includes conditions in which there is progressive destruction of hepatic cells and replacement with fibrosis from alcohol consumption.

Total sources
Incidence 0
Prevalence 0
Remission 0
Causes of death 3828
Other 54
Table 1: Total sources used in GBD 2019 estimation
What is new in GBD 2019?
  • •Bias adjustment for claims data to hospital data in the USA was estimated using MR-BRT and applied to data, lowering claims data values differentially by age prior to analysis in DisMod-MR 2.1.
  • •Excess mortality data (EMR) were modelled in MR-BRT by age and sex as a function of the HAQ Index to provide greater guidance to DisMod-MR on expected pattern of EMR.
  • •We added mild, moderate, and severe anaemia health states to decompensated cirrhosis based on a review of the mean haemoglobin shift of 18 g/L in people with cirrhosis.
Prevalence
Incidence
Deaths
YLLs
YLDs
DALYs
Cases
(millions)
Rate (per 100 000)
Cases
(millions)
Rate (per 100 000)
Deaths
(millions)
Rate (per 100 000)
YLLs
(millions)
Rate (per 100 000)
YLDs
(millions)
Rate (per 100 000)
DALYs
(millions)
Rate (per 100 000)
2019
Both Sexes
14·8
(12·1
to 18·1)
176·3
(144·0
to 214·3)
0·436
(0·315
to 0·579)
5·2
(3·8
to 6·9)
0·372
(0·315
to 0·438)
4·5
(3·8
to 5·3)
11·0
(9·31
to 12·9)
131·3
(111·0
to 154·3)
0·166
(0·112
to 0·242)
2·0
(1·3
to 2·9)
11·2
(9·45
to 13·1)
133·3
(112·7
to 156·2)
Females
4·67
(3·74
to 5·77)
108·2
(87·1
to 133·6)
0·141
(0·100
to 0·192)
3·4
(2·4
to 4·5)
0·0972
(0·0793
to 0·119)
2·2
(1·8
to 2·7)
2·60
(2·12
to 3·15)
60·3
(49·2
to 72·9)
0·0456
(0·0303
to 0·0672)
1·1
(0·7
to 1·6)
2·64
(2·17
to 3·19)
61·4
(50·4
to 73·9)
Males
10·2
(8·33
to 12·3)
246·7
(202·7
to 297·5)
0·295
(0·212
to 0·391)
7·1
(5·1
to 9·4)
0·275
(0·234
to 0·321)
6·9
(5·9
to 8·1)
8·42
(7·14
to 9·83)
205·1
(174·2
to 238·6)
0·121
(0·0815
to 0·176)
2·9
(2·0
to 4·3)
8·54
(7·27
to 9·94)
208·1
(177·5
to 242·1)
Percentage change 2010-19
Both Sexes
24·6%
(20·0
to 28·7)
1·8%
(–1·6
to 5·1)
17·4%
(9·4
to 23·8)
2·9%
(–4·0
to 8·0)
14·3%
(7·9
to 20·9)
–8·9%
(–13·9
to –3·9)
10·7%
(4·2
to 17·3)
–9·5%
(–14·6
to –4·1)
24·7%
(20·3
to 29·3)
2·0%
(–1·4
to 5·6)
10·9%
(4·5
to 17·4)
–9·3%
(–14·3
to –4·0)
Females
25·8%
(21·1
to 30·2)
1·7%
(–1·9
to 5·0)
21·5%
(13·1
to 28·0)
4·1%
(–2·6
to 8·9)
15·4%
(7·9
to 22·8)
–9·2%
(–15·1
to –3·6)
11·2%
(3·4
to 18·7)
–10·3%
(–16·5
to –4·3)
23·4%
(18·0
to 28·8)
–0·4%
(–4·7
to 3·6)
11·4%
(3·6
to 18·7)
–10·2%
(–16·2
to –4·2)
Males
24·0%
(19·4
to 28·2)
1·9%
(–1·5
to 5·2)
15·6%
(6·7
to 22·1)
2·4%
(–4·8
to 7·9)
13·9%
(6·8
to 21·3)
–8·8%
(–14·3
to –3·0)
10·6%
(3·2
to 18·1)
–9·2%
(–15·0
to –2·9)
25·2%
(20·6
to 29·9)
3·0%
(–0·7
to 6·8)
10·8%
(3·6
to 18·1)
–9·0%
(–14·7
to –2·8)
Numbers in parentheses are 95% uncertainty intervals.
Table 2: Global prevalence, incidence, deaths, YLLs, YLDs, and DALYs in counts and age-standardised rates for both sexes combined, females, and males, 2019, with percentage change between 2010 and 2019
Deaths YLLs YLDs DALYs
1990 40th 50th 209th 68th
2010 35th 41st 199th 59th
2019 33rd 35th 196th 52nd
Table 3: Rank among most detailed causes for global deaths, YLLs, YLDs, and DALYs in 1990, 2010, and 2019, for both sexes combined
Figure 1: Composition of DALYs by YLLs and YLDs for both sexes combined, 2019
Figure 2: Percentage of DALYs attributable to top risk factors for both sexes combined, 2019
No Legend
Figure 3: Age-standardised DALY rates for each location by SDI, both sexes combined, 2019
Figure 4: Composition of DALYs by YLLs and YLDs, age group, and sex, 2019
No Legend
Figure 5: Age-standardised DALY rates (per 100 000) by location, both sexes combined, 2019