Summary Cirrhosis and other chronic liver diseases due to hepatitis C resulted in 12·2 million (95% UI 10·3–14·2) global DALYs in 2019 and was responsible for 26·3% (22·9–30·5) of cirrhosis DALYs.

Definition Cirrhosis and other chronic liver diseases due to hepatitis C includes conditions in which there is progressive destruction of functional hepatic cells and replacement with fibrosis of the liver from hepatitis virus.

Total sources
Incidence 0
Prevalence 0
Remission 0
Causes of death 3828
Other 85
Table 1: Total sources used in GBD 2019 estimation
What is new in GBD 2019?
  • •Bias adjustment for claims data to hospital data in the USA was estimated using in MR-BRT and applied to data, lowering claims data values differentially by age prior to analysis in DisMod-MR 2.1.
  • •Excess mortality data (EMR) were modelled in MR-BRT by age and sex as a function of the HAQ Index to provide greater guidance to DisMod-MR on expected pattern of EMR.
  • •We added mild, moderate, and severe anaemia health states to decompensated cirrhosis based on a review of the mean haemoglobin shift of 18 g/L in people with cirrhosis.
Prevalence
Incidence
Deaths
YLLs
YLDs
DALYs
Cases
(millions)
Rate (per 100 000)
Cases
(millions)
Rate (per 100 000)
Deaths
(millions)
Rate (per 100 000)
YLLs
(millions)
Rate (per 100 000)
YLDs
(millions)
Rate (per 100 000)
DALYs
(millions)
Rate (per 100 000)
2019
Both Sexes
112
(91·2
to 138)
1414·7
(1146·8
to 1744·7)
0·552
(0·409
to 0·711)
6·7
(5·0
to 8·6)
0·395
(0·336
to 0·459)
4·8
(4·1
to 5·6)
12·0
(10·2
to 14·0)
144·4
(122·7
to 167·8)
0·157
(0·106
to 0·228)
1·9
(1·3
to 2·8)
12·2
(10·3
to 14·2)
146·2
(124·4
to 169·8)
Females
58·4
(47·3
to 71·8)
1456·7
(1180·4
to 1799·2)
0·213
(0·158
to 0·276)
5·1
(3·8
to 6·6)
0·127
(0·105
to 0·149)
2·9
(2·4
to 3·4)
3·47
(2·89
to 4·13)
81·5
(68·0
to 96·7)
0·0546
(0·0363
to 0·0793)
1·3
(0·9
to 1·9)
3·52
(2·95
to 4·18)
82·8
(69·3
to 98·0)
Males
54·0
(43·9
to 66·4)
1370·5
(1113·4
to 1683·8)
0·339
(0·251
to 0·439)
8·2
(6·1
to 10·6)
0·268
(0·229
to 0·311)
6·9
(5·9
to 7·9)
8·53
(7·19
to 9·98)
209·3
(177·0
to 243·6)
0·103
(0·0686
to 0·149)
2·5
(1·7
to 3·7)
8·63
(7·28
to 10·1)
211·8
(179·4
to 246·9)
Percentage change 2010-19
Both Sexes
15·8%
(13·9
to 17·7)
1·4%
(–0·3
to 3·2)
20·1%
(13·8
to 25·9)
5·6%
(0·3
to 10·2)
15·3%
(8·3
to 22·3)
–7·4%
(–12·6
to –1·9)
10·3%
(3·3
to 17·5)
–8·3%
(–14·0
to –2·4)
26·0%
(21·4
to 30·3)
4·9%
(1·3
to 8·2)
10·5%
(3·5
to 17·7)
–8·2%
(–13·8
to –2·4)
Females
17·5%
(15·3
to 19·9)
2·7%
(0·6
to 4·7)
23·2%
(16·3
to 29·5)
6·3%
(1·1
to 10·8)
15·8%
(6·7
to 24·1)
–8·1%
(–15·1
to –1·4)
10·2%
(1·2
to 19·2)
–9·3%
(–16·8
to –1·8)
24·9%
(19·4
to 30·0)
2·8%
(–1·3
to 6·6)
10·4%
(1·5
to 19·3)
–9·2%
(–16·4
to –1·8)
Males
13·9%
(12·1
to 15·8)
0·0%
(–1·9
to 1·8)
18·2%
(11·8
to 23·9)
5·1%
(–0·6
to 9·8)
15·1%
(7·0
to 23·3)
–7·1%
(–13·3
to –0·8)
10·3%
(2·0
to 18·6)
–7·8%
(–14·7
to –1·0)
26·6%
(21·4
to 31·5)
6·0%
(1·9
to 10·0)
10·5%
(2·3
to 18·7)
–7·7%
(–14·5
to –1·0)
Numbers in parentheses are 95% uncertainty intervals.
Table 2: Global prevalence, incidence, deaths, YLLs, YLDs, and DALYs in counts and age-standardised rates for both sexes combined, females, and males, 2019, with percentage change between 2010 and 2019
Deaths YLLs YLDs DALYs
1990 37th 45th 207th 64th
2010 30th 38th 204th 52nd
2019 30th 29th 199th 47th
Table 3: Rank among most detailed causes for global deaths, YLLs, YLDs, and DALYs in 1990, 2010, and 2019, for both sexes combined
Figure 1: Composition of DALYs by YLLs and YLDs for both sexes combined, 2019
Figure 2: Percentage of DALYs attributable to top risk factors for both sexes combined, 2019
No Legend
Figure 3: Age-standardised DALY rates for each location by SDI, both sexes combined, 2019
Figure 4: Composition of DALYs by YLLs and YLDs, age group, and sex, 2019
No Legend
Figure 5: Age-standardised DALY rates (per 100 000) by location, both sexes combined, 2019