Summary CMNN diseases caused 10·2 million (95% UI 9·19–11·4) deaths, 669 million (593–758) DALYs, and 104 million (77·1–137) YLDs, in 2019 globally for all ages, which represented a 36·3% (29·1–42·3) decrease in deaths, a 44·4% (37·4–50·5) decrease in DALYs, and a 22·1% (18·2–26·8) increase in YLDs from 1990.

Definition This aggregate cause contains seven Level 2 causes: HIV/AIDS and sexually-transmitted infections, respiratory infections and tuberculosis, enteric infections, neglected tropical diseases and malaria, other infectious diseases, maternal and neonatal disorders, and nutritional deficiencies.

Total sources
Incidence 24578
Prevalence 8671
Remission 7
Causes of death 6302
Other 22028
Table 1: Total sources used in GBD 2019 estimation
What is new in GBD 2019?
  • •Where applicable, both-sex and wide-age-binned data were split prior to non-fatal modelling. Adjustment for alternative study methods and case definitions were applied to data prior to analysis in DisMod-MR 2.1.
  • •A systematic review found 81 new data sources for both maternal deaths and non-fatal outcomes.
  • •Clinical administrative data processing was revised to better account for neonatal inpatient:outpatient visits.
  • •Improved redistribution of sepsis and jaundice garbage-coded deaths led to changes in cause-specific mortality assessment for neonatal disorders, especially in the post-neonatal period.
  • •Model-specific covariates were updated for both cause-of-death and non-fatal modelling for nutritional deficiencies.
Prevalence
Incidence
Deaths
YLLs
YLDs
DALYs
Cases
(millions)
Rate (per 100 000)
Cases
(millions)
Rate (per 100 000)
Deaths
(millions)
Rate (per 100 000)
YLLs
(millions)
Rate (per 100 000)
YLDs
(millions)
Rate (per 100 000)
DALYs
(millions)
Rate (per 100 000)
2019
Both Sexes
4540
(4420
to 4650)
58 287·4
(56 841·8
to 59 728·8)
26 400
(24 600
to 28 500)
346 347·1
(321 319·5
to 374 145·2)
10·2
(9·19
to 11·4)
140·7
(126·8
to 157·9)
564
(498
to 653)
8106·0
(7096·7
to 9392·4)
104
(77·1
to 137)
1377·3
(1016·8
to 1811·6)
669
(593
to 758)
9483·4
(8394·5
to 10 801·7)
Females
2350
(2290
to 2410)
60 553·8
(59 080·0
to 62 023·6)
13 000
(12 100
to 14 000)
342 135·6
(317 260·2
to 369 373·5)
4·85
(4·30
to 5·52)
130·7
(115·4
to 148·3)
263
(232
to 301)
7704·8
(6764·5
to 8858·5)
56·0
(41·1
to 74·1)
1484·6
(1088·9
to 1964·8)
319
(283
to 360)
9189·4
(8098·3
to 10 408·1)
Males
2180
(2120
to 2240)
56 034·1
(54 541·1
to 57 546·1)
13 500
(12 500
to 14 500)
350 854·1
(326 058·9
to 379 037·3)
5·34
(4·82
to 6·02)
152·7
(137·6
to 171·9)
301
(263
to 350)
8511·9
(7408·9
to 9950·5)
48·3
(35·8
to 63·4)
1272·5
(939·5
to 1668·3)
349
(309
to 399)
9784·5
(8628·8
to 11 226·3)
Percentage change 2010-19
Both Sexes
7·1%
(6·3
to 7·9)
–3·5%
(–4·3
to –2·8)
12·6%
(11·5
to 13·7)
2·5%
(1·6
to 3·4)
–19·3%
(–25·1
to –12·6)
–27·6%
(–33·0
to –21·5)
–27·8%
(–34·8
to –19·5)
–30·9%
(–37·8
to –22·8)
9·1%
(7·2
to 11·6)
–0·3%
(–2·0
to 1·9)
–23·8%
(–30·1
to –16·4)
–27·7%
(–34·0
to –20·4)
Females
8·0%
(7·2
to 8·7)
–3·0%
(–3·8
to –2·4)
12·6%
(11·5
to 13·8)
2·4%
(1·4
to 3·4)
–19·6%
(–25·6
to –12·0)
–28·5%
(–34·2
to –21·8)
–29·0%
(–35·7
to –21·0)
–32·1%
(–38·9
to –24·3)
9·2%
(7·3
to 11·3)
–0·5%
(–2·1
to 1·4)
–24·3%
(–30·4
to –17·3)
–28·4%
(–34·4
to –21·3)
Males
6·2%
(5·3
to 7·1)
–4·1%
(–4·9
to –3·3)
12·6%
(11·5
to 13·7)
2·6%
(1·6
to 3·5)
–19·0%
(–25·4
to –12·1)
–26·9%
(–32·5
to –20·6)
–26·7%
(–34·2
to –18·2)
–29·8%
(–37·1
to –21·2)
9·1%
(6·8
to 12·0)
–0·2%
(–2·3
to 2·4)
–23·2%
(–30·0
to –15·7)
–27·0%
(–33·6
to –19·4)
Numbers in parentheses are 95% uncertainty intervals.
Table 2: Global prevalence, incidence, deaths, YLLs, YLDs, and DALYs in counts and age-standardised rates for both sexes combined, females, and males, 2019, with percentage change between 2010 and 2019
Deaths YLLs YLDs DALYs
1990 2nd 1st 2nd 1st
2010 2nd 2nd 2nd 2nd
2019 2nd 2nd 2nd 2nd
Table 3: Rank among Level 1 causes for global deaths, YLLs, YLDs, and DALYs in 1990, 2010, and 2019, for both sexes combined
Figure 1: Composition of DALYs by constituent Level 2 causes for both sexes combined, 2019
Figure 2: Percentage of DALYs attributable to top risk factors for both sexes combined, 2019
No Legend
Figure 3: Age-standardised DALY rates for each location by SDI, both sexes combined, 2019
Figure 4: Composition of DALYs by YLLs and YLDs, age group, and sex, 2019
No Legend
Figure 5: Age-standardised DALY rates (per 100 000) by location, both sexes combined, 2019