Summary Globally in 2019, the number of HIV-related deaths was 864 000 (95% UI 786 000–996 000) and the number of new HIV infections was 1·99 million (1·76–2·26). The majority of this burden was seen in the sub-Saharan Africa super-region, which accounted for 74·0% (71·4–76·9) of global HIV-related deaths and 64·9% (61·1–69·1) of new HIV infections in 2019.

Definition The human immunodeficiency virus (HIV) causes influenza-like symptoms during the acute period following infection, and can lead to acquired immunodeficiency syndrome (AIDS) if untreated. HIV attacks the immune system, leaving infected individuals more susceptible to opportunistic infections like tuberculosis. We do not distinguish between HIV-1 and HIV-2.

Total sources
Incidence 1092
Prevalence 107
Remission 0
Causes of death 1311
Other 5232
Table 1: Total sources used in GBD 2019 estimation
What is new in GBD 2019?
  • •To estimate age-specific and sex-specific HIV incidence, prevalence, and mortality in countries in sub-Saharan Africa, we switched from using Spectrum to a new model—Estimation and Projection Package—Age-Sex Model (EPP-ASM).
  • •Bias associated with the location of antenatal care (ANC) clinics was adjusted using spatial information. This adjustment was an improvement on our previous method, which imputed earlier years of prevalence data based on regional averages of the epidemic peak year.
Prevalence
Incidence
Deaths
YLLs
YLDs
DALYs
Cases
(millions)
Rate (per 100 000)
Cases
(millions)
Rate (per 100 000)
Deaths
(millions)
Rate (per 100 000)
YLLs
(millions)
Rate (per 100 000)
YLDs
(millions)
Rate (per 100 000)
DALYs
(millions)
Rate (per 100 000)
2019
Both Sexes
36·8
(35·1
to 38·9)
454·3
(433·8
to 478·6)
1·99
(1·76
to 2·26)
25·2
(22·4
to 28·6)
0·864
(0·786
to 0·996)
10·7
(9·7
to 12·4)
43·6
(38·4
to 51·6)
552·0
(482·7
to 655·5)
4·01
(2·83
to 5·40)
49·5
(35·1
to 66·6)
47·6
(42·6
to 55·7)
601·5
(536·2
to 703·9)
Females
20·1
(19·3
to 20·9)
497·9
(478·4
to 518·7)
0·999
(0·862
to 1·17)
25·7
(22·3
to 30·0)
0·428
(0·383
to 0·502)
10·7
(9·5
to 12·6)
22·1
(19·1
to 26·5)
565·9
(487·3
to 681·2)
2·20
(1·58
to 2·94)
54·8
(39·3
to 73·2)
24·3
(21·4
to 28·6)
620·7
(544·0
to 734·0)
Males
16·8
(15·6
to 18·4)
412·3
(383·0
to 450·7)
0·991
(0·878
to 1·11)
24·8
(22·0
to 27·8)
0·435
(0·399
to 0·500)
10·7
(9·8
to 12·4)
21·5
(19·2
to 25·4)
539·0
(477·4
to 636·6)
1·81
(1·26
to 2·49)
44·4
(30·9
to 61·1)
23·3
(21·1
to 27·1)
583·3
(525·7
to 679·6)
Percentage change 2010-19
Both Sexes
23·3%
(19·2
to 26·7)
9·5%
(5·9
to 12·7)
–16·1%
(–22·3
to –8·1)
–23·2%
(–29·0
to –15·8)
–36·8%
(–40·0
to –32·6)
–43·9%
(–46·4
to –40·6)
–40·5%
(–43·3
to –36·7)
–46·3%
(–48·7
to –43·2)
–1·6%
(–17·6
to 12·6)
–12·3%
(–26·6
to 0·4)
–38·5%
(–41·4
to –34·7)
–44·6%
(–47·1
to –41·4)
Females
23·6%
(19·1
to 27·4)
10·2%
(6·1
to 13·6)
–21·1%
(–27·3
to –13·3)
–27·0%
(–32·9
to –19·5)
–42·4%
(–45·2
to –38·8)
–48·7%
(–51·0
to –45·9)
–45·4%
(–47·9
to –42·1)
–50·5%
(–52·8
to –47·7)
–2·9%
(–20·4
to 13·0)
–13·0%
(–28·8
to 1·3)
–43·1%
(–45·9
to –40·0)
–48·6%
(–51·0
to –45·9)
Males
22·8%
(18·8
to 26·8)
8·8%
(5·2
to 12·2)
–10·4%
(–17·0
to –2·0)
–19·0%
(–25·1
to –11·2)
–30·1%
(–33·6
to –25·1)
–38·0%
(–41·0
to –34·1)
–34·6%
(–37·6
to –30·1)
–41·1%
(–43·8
to –37·3)
0·0%
(–13·5
to 12·8)
–11·2%
(–23·4
to 0·1)
–32·8%
(–36·0
to –28·5)
–39·6%
(–42·3
to –35·8)
Numbers in parentheses are 95% uncertainty intervals.
Table 2: Global prevalence, incidence, deaths, YLLs, YLDs, and DALYs in counts and age-standardised rates for both sexes, females, and males, 2019, with percentage change between 2010 and 2019
Deaths YLLs YLDs DALYs
1990 30th 22nd 76th 30th
2010 8th 6th 44th 7th
2019 17th 12th 48th 11th
Table 3: Rank among Level 3 causes for global deaths, YLLs, YLDs, and DALYs in 1990, 2010, and 2019, for both sexes combined
Figure 1: Composition of DALYs by constituent Level 4 causes for both sexes combined, 2019
Figure 2: Percentage of DALYs attributable to top risk factors, 2019
No Legend
Figure 3: Age-standardised DALY rates for each location by SDI, 2019
Figure 4: Composition of DALYs by YLLs and YLDs, age group, and sex, 2019
No Legend
Figure 5: Age-standardised DALY rates (per 100 000) by location, both sexes, 2019