Biography
Hmwe Hmwe Kyu, MBBS, MPH, PhD, is an Assistant Professor of Health Metrics Sciences at the Institute for Health Metrics and Evaluation (IHME) and an Adjunct Assistant Professor of Global Health in the Department of Global Health at the University of Washington. At IHME, she leads the research team that focuses on modeling the burden of HIV/AIDS, tuberculosis, diarrheal diseases, lower respiratory infections, upper respiratory infections, meningitis, encephalitis, and otitis media for the institute’s landmark Global Burden of Disease study.
Dr. Kyu’s research interests are in the areas of infectious disease epidemiology, child and adolescent health, systematic review methods, and multilevel modeling. Before joining IHME, she was a postdoctoral fellow at McMaster University and the Offord Centre for Child Studies in Hamilton, Canada, and was a recipient of a Lawson postdoctoral fellowship. Her doctoral and postdoctoral research focused on how individual and contextual factors (at the country, community, and household levels) influence childhood diseases and mortality, especially in low- and middle-income countries.
Dr. Kyu earned her medical degree from Institute of Medicine, Mandalay, Myanmar, her MPH from Chulalongkorn University in Bangkok, Thailand, and her PhD in Health Research Methodology from McMaster University in Canada.
IHME was established at the University of Washington in Seattle in 2007. Its mission is to deliver to the world timely, relevant, and scientifically valid evidence to improve health policy and practice.
Bender RG, Shen J, Aravkin A, et al. Meningococcal A conjugate vaccine coverage in the meningitis belt of Africa from 2010 to 2021: A modelling study. eClinicalMedicine. 5 January 2023. doi:10.1016/j.eclinm.2022.101797.
Ma J, Vongpradith A, Ledesma JR. Progress towards the 2020 milestones of the end TB strategy in Cambodia: estimates of age and sex specific TB incidence and mortality from the Global Burden of Disease Study 2019. BMC Infectious Diseases. 3 December 2022. doi: 10.1186/s12879-022-07891-5.
GBD 2019 Antimicrobial Resistance Collaborators. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 21 November 2022. doi: 10.1016/
S0140-6736(22)02185-7.
European Antimicrobial Resistance Collaborators. The burden of bacterial antimicrobial resistance in the WHO European region in 2019: a cross-country systematic analysis. The Lancet Public Health. 13 October 2022. doi: 10.1016/S2468-2667(22)00225-0
GBD 2019 Indonesia Subnational Collaborators. The state of health in Indonesia’s provinces, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Global Health. 11 October 2022. doi: 10.1016/S2214-109X(22)00371-0.
GBD 2019 Healthcare Access and Quality Collaborators. Assessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019. The Lancet Global Health. 6 October 2022. doi: 10.1016/S2214-109X(22)00429-6.
Zou Z, Liu G, Hay SI, et al. Time trends in tuberculosis mortality across the BRICS: an age-period-cohort analysis for the GBD 2019. eClinicalMedicine. 16 September 2022. doi: 10.1016/j.eclinm.2022.101646.
GBD 2019 LRI Collaborators. Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019. The Lancet Infectious Diseases. 11 August 2022. doi: 10.1016/S1473-3099(22)00510-2.
Janko MM, Joffe J, Michael D, et al. Cost-effectiveness of rotavirus vaccination in children under five years of age in 195 countries: A meta-regression analysis. Vaccine. 21 June 2022. doi: 10.1016/j.vaccine.2022.05.042.
Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 20 January 2022. doi:10.1016/S0140-6736(21)02724-0.
Ross JM, Xie Y, Wang Y, Collins JK, Horst C, Doody JB, Lindstedt P, Ledesma JR, Shapiro AE, Hay SI, Kyu HH, Flaxman AD. Estimating the population at high risk for tuberculosis through household exposure in high-incidence countries: a model-based analysis. EClinicalMedicine. 21 November 2022. doi:10.1016/j.eclinm.2021.101206.
GBD 2019 HIV Collaborators. Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019. The Lancet HIV. 27 September 2021. doi: 10.1016/S2352-3018(21)00152-1.
GBD 2019 Tuberculosis Collaborators. Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990–2019: results from the Global Burden of Disease Study 2019. The Lancet Infectious Diseases. 23 September 2021. doi: 10.1016/S1473-3099(21)00449-7.
Kyu HH, Jahagirdar D, Cunningham M, Walters M, Brewer E, Novotney A, Wool E, Dippennar I, Sharara F, Han C, Balassyano S, Bertolacci G, Murray CJL, Naghavi M. Accounting for misclassified and unknown cause of death data in vital registration systems for estimating trends in HIV mortality. Journal of the International AIDS Society. 21 September 2021. doi: 10.1002/jia2.25791.
India State-Level Disease Burden Initiative Neurological Disorders Collaborators. The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019. The Lancet Global Health. 13 July 2021. doi:10.1016/S2214-109X(21)00164-9.
Jahagirdar D, Walters M, Vongpradith A, Dai X, Novotney A, Kyu HH, Wang H. Incidence of HIV in Sub-Saharan Africa, 2000–2015: The Interplay Between Social Determinants and Behavioral Risk Factors. AIDS and Behavior. 05 June 2021. doi: 10.1007/s10461-021-03279-9.
Local Burden of Disease HIV Collaborators. Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study. The Lancet HIV. 1 June 2021. doi:10.1016/S2352-3018(21)00051-5.
Wright C, Blake N, Glennie L, Smith V, Bender R, Kyu H, Wunrow HY, Liu L, Yeung D, Knoll MD, Wahl B, Stuart JM, and Trotter C. The Global Burden of Meningitis in Children: Challenges with Interpreting Global Health Estimates. Microorganisms. 13 February 2021. doi: 10.3390/microorganisms9020377.
GBD 2019 Universal Health Coverage Collaborators. Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 27 August 2020. doi:10.1016/S0140-6736(20)30750-9.
India State-Level Disease Burden Initiative Child Mortality Collaborators. Subnational mapping of under-5 and neonatal mortality trends in India: the Global Burden of Disease Study 2000–17. The Lancet. 11 May 2020. doi:10.1016/S0140-6736(20)30471-2.
GBD 2017 Lower Respiratory Infections Collaborators. Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: an analysis for the Global Burden of Disease Study 2017. The Lancet Infectious Diseases. 30 October 2019. doi:10.1016/S1473-3099(19)30410-4.
GBD 2017 Diarrhoeal Disease Collaborators. Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. The Lancet Infectious Diseases. 30 October 2019. doi:10.1016/S1473-3099(19)30559-6.
GBD 2017 HIV Collaborators. Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. The Lancet HIV. 14 August 2019. doi:10.1016/S2352-3018(19)30196-1.
GBD 2017 Child and Adolescent Health Collaborators. Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017. JAMA Pediatrics. 29 April 2019. doi:10.1001/jamapediatrics.2019.0337.
GBD Tuberculosis Collaborators. Global, regional, and national burden of tuberculosis, 1990–2016: results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study. The Lancet Infectious Diseases. 1 Dec 2018. doi:10.1016/S1473-3099(18)30625-X.
GBD 2017 SDG Collaborators. Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 8 Nov 2018; 392:2091–138. doi: http://dx.doi.org/10.1016/S0140-6736(18)32281-5.
GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 8 Nov 2018;392:1736-88. doi: http://dx.doi.org/10.1016/S0140-6736(18)32203-7.
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 8 Nov 2018;392:1789–858. doi: http://dx.doi.org/10.1016/S0140-6736(18)32279-7.
GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 8 Nov 2018;392:1859–922. doi: http://dx.doi.org/10.1016/S0140-6736(18)32335-3.
GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 8 Nov 2018;392:1923-94. doi: http://dx.doi.org/10.1016/S0140-6736(18)32225-6.
Wiens KE, Woyczynski LP, Ledesma JR, Ross JM, Zenteno-Cuevas R, Goodridge A, Ullah I, Mathema B, Siawaya JFL, Biehl MH, Ray SE, Bhattacharjee NV, Henry NJ, Reiner RC, Kyu HH, Murray CJL, Hay SI. Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis. BMC Medicine. 30 Oct 2018;16(1):196. doi:10.1186/s12916-018-1180-x.
Ross JM, Henry NJ, Dwyer-Lindgren LA, de Paula Lobo A, Marinho de Souza F, Biehl MH, Ray SE, Reiner RC, Stubbs RW, Wiens KE, Earl L, Kutz MJ, Bhattacharjee NV, Kyu HH, Naghavi M, Hay SI. Progress toward eliminating TB and HIV deaths in Brazil, 2001–2015: a spatial assessment. BMC Medicine. 6 September 2018. doi:10.1186/s12916-018-1131-6.
GBD 2016 Healthcare Access and Quality Collaborators. Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016. The Lancet. 23 May 2018.
US Burden of Disease Collaborators. The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States. JAMA. 10 April 2018; 319(14):1-33. doi:10.1001/jama.2018.0158
Kyu HH, Stein CE, Boschi Pinto C, et al. Causes of death among children aged 5–14 years in the WHO European Region: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Child & Adolescent Health. 2018 Mar 19. doi: 10.1016/S2352-4642(18)30095-6.
GBD Tuberculosis Collaborators. The global burden of tuberculosis: results from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 Study. Lancet Infectious Diseases. 2018; 18(3):261-284. PMCID: PMC5831985
India State-level Disease Burden Initiative Collaborators. Nations within a nation: variations in epidemiological transition across the states of India, 1990–2016 in the Global Burden of Disease Study. The Lancet. 13 Nov 2017. doi: http://dx.doi.org/10.1016/S0140-6736(17)32804-0
GBD 2015 Neurological Disorders Collaborator Group. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet Neurology. 17 Sept 2017. doi: http://dx.doi.org/10.1016/S1474-4422(17)30299-5.
GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 14 Sept 2017: 390;1151–210.
GBD 2016 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 14 Sept 2017: 390;1260-344.
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 14 Sept 2017: 390; 1211–59.
GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 14 Sept 2017: 390;1345-1422.
GBD 2016 SDG Collaborators. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. The Lancet. 12 Sept 2017: 390; 1423–59.
GBD 2015 Eastern Mediterranean Region Collaborators. Danger ahead: the burden of diseases, injuries, and risk factors 3 in the Eastern Mediterranean Region, 1990–2015. International Journal of Public Health. 7 Aug 2017.
GBD 2015 Eastern Mediterranean Region Collaborators. Adolescent health in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study. International Journal of Public Health. 7 Aug 2017.
GBD 2015 Eastern Mediterranean Region Collaborators. Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study. International Journal of Public Health. 7 Aug 2017.
GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal healthcare in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease 2015 study. The Lancet. 2017 May 18.
The Global Burden of Disease Child and Adolescent Health Collaboration. Child and adolescent health from 1990 to 2015: Findings from the Global Burden of Disease, Injuries, and Risk Factors 2015 Study. JAMA Pediatrics. 2017;171(6):1-21. doi:10.1001/jamapediatrics.2017.0250.
Kyu HH, Mumford JE, Stanaway JD, Barber RM, Hancock JR, Vos T, Murray CJL, Naghavi M. Mortality from tetanus between 1990 and 2015: findings from the global burden of disease study 2015. BMC Public Health. 2017 Feb 8. doi: 10.1186/s12889-017-4111-4.
GBD 2015 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioral, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016 Oct 7; 388:1659–1724.
GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016 Oct 7; 388:1603–1658.
GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016 Oct 7; 388:1459–1544.
GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016 Oct 7; 388:1545–1602.
GBD 2015 Child Mortality Collaborators. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016 Oct 7; 388:1725–1774.
Lim SS, Allen K, Bhutta ZA, et al. Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015. The Lancet. 2016 Sep 21. doi: 10.1016/S0140-6736(16)31467-2.
Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, Veerman JL, Delwiche K, Iannarone ML, Moyer ML, Cercy K, Vos T, Murray CJL, Forouzanfar MH. Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013. the BMJ. 9 Aug 2016; 354:i3857. doi: 10.1136/bmj.i3857
Wang H, Wolock TM, Carter A, et al. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015. The Lancet HIV. 2016 Jul 19. doi: 10.1016/S2352-3018(16)30087-X.
Mokdad AH, Forouzanfar MH, Daoud F, et al. Global burden of diseases, injuries, and risk factors for young people’s health during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2016 May 9. doi: 10.1016/S0140-6736(16)00648-6.
Kyu HH, Pinho C, Wagner JA, et al. Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: Findings from the Global Burden of Disease 2013 study. JAMA Pediatrics. 2015 Jan 25. doi: 10.1001/jamapediatrics.2015.4276.
Forouzanfar MH, Alexander L, Anderson HR, et al. Global, regional, and national comparative risk assessment of 79 behavioral, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2015 Sep 11. doi: 10.1016/S0140-6736(15)61455-6.
Murray CJL, Barber RM, Foreman KJ, et al. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. The Lancet. 2015 Aug 27. doi: 10.1016/S0140-6736(15)61340-X.
Pigott DM, Howes RE, Wiebe A, Battle KE, Golding N, Gething PW, Dowell SF, Farag TH, Garcia AJ, Kimball AM, Krause LK, Smith CH, Brooker SJ, Kyu HH, Vos T, Murray CJL, Moyes CL, Hay SI. Prioritizing infectious disease mapping. PLOS Neglected Tropical Diseases. 2015 Jun 10. doi: 10.1371/journal.pntd.0003756.
Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2015 June 8. doi: 10.1016/S0140-6736(15)60692-4.
Naghavi M, Wang H, Lozano R, et al. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2014 Dec 17. doi: 10.1016/S0140-6736(14)61682-2.