Burden of disease in Brazil, 1990–2016: a systematic subnational analysis for the Global Burden of Disease Study 2016

Published July 20, 2018, in The Lancet (opens in a new window)


Political, economic, and epidemiological changes in Brazil have affected health and the health system. We used the Global Burden of Disease Study 2016 (GBD 2016) results to understand changing health patterns and inform policy responses.


We analyzed GBD 2016 estimates for life expectancy at birth (LE), healthy life expectancy (HALE), all-cause and cause-specific mortality, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life years (DALYs), and risk factors for Brazil, its 26 states, and the Federal District from 1990 to 2016, and compared these with national estimates for ten comparator countries.


Nationally, LE increased from 68.4 years (95% uncertainty interval [UI] 68.0–68.9) in 1990 to 75.2 years (74.7–75.7) in 2016, and HALE increased from 59.8 years (57.1–62.1) to 65.5 years (62.5–68.0). All-cause age-standardized mortality rates decreased by 34.0% (33.4–34.5), while all-cause age-standardized DALY rates decreased by 30.2% (27.7–32.8); the magnitude of declines varied among states. In 2016, ischemic heart disease was the leading cause of age-standardized YLLs, followed by interpersonal violence. Low back and neck pain, sense organ diseases, and skin diseases were the main causes of YLDs in 1990 and 2016. Leading risk factors contributing to DALYs in 2016 were alcohol and drug use, high blood pressure, and high body mass index.


Health improved from 1990 to 2016, but improvements and disease burden varied between states. An epidemiological transition toward non-communicable diseases and related risks occurred nationally, but later in some states, while interpersonal violence grew as a health concern. Policymakers can use these results to address health disparities.

Read full article (opens in a new window)


GBD 2016 Brazil Collaborators. Burden of disease in Brazil, 1990–2016: a systematic subnational analysis for the Global Burden of Disease Study 2016. The Lancet. 20 July 2018. doi:10.1016/S0140-6736(18)31221-2.


Scientific Publication

Global burden of peripheral artery disease and its risk factors, 1990–2019

Scientific Publication

Hepatitis B and C in Europe

Scientific Publication

Global, regional, and national burden of meningitis and its aetiologies, 1990–2019