Abstract
Previous research suggests detrimental health effects associated with consuming processed foods, including processed meats, sugar-sweetened beverages (SSBs) and trans fatty acids (TFAs). However, systematic characterization of the dose–response relationships between these foods and health outcomes is limited. Here, using Burden of Proof meta-regression methods, we evaluated the associations between processed meat, SSBs and TFAs and three chronic diseases: type 2 diabetes, ischemic heart disease (IHD) and colorectal cancer. We conservatively estimated that—relative to zero consumption—consuming processed meat (at 0.6–57 g d−1) was associated with at least an 11% average increase in type 2 diabetes risk and a 7% (at 0.78–55 g d−1) increase in colorectal cancer risk. SSB intake (at 1.5–390 g d−1) was associated with at least an 8% average increase in type 2 diabetes risk and a 2% (at 0–365 g d−1) increase in IHD risk. TFA consumption (at 0.25–2.56% of daily energy intake) was associated with at least a 3% average increase in IHD risk. These associations each received two-star ratings reflecting weak relationships or inconsistent input evidence, highlighting both the need for further research and—given the high burden of these chronic diseases—the merit of continuing to recommend limiting consumption of these foods.
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Citation
Haile D, Harding KL, McGlaughlin SL, et al. Health effects associated with consumption of processed meat, sugar-sweetened beverages and trans fatty acids: a Burden of Proof study. Nature Medicine. 30 June 2025. doi: 10.1038/s41591-025-03775-8.
