As a leading behavioral risk factor for numerous health outcomes, smoking is a major ongoing public health challenge. Although evidence on the health effects of smoking has been widely reported, few attempts have evaluated the dose–response relationship between smoking and a diverse range of health outcomes systematically and comprehensively. In the present study, we re-estimated the dose–response relationships between current smoking and 36 health outcomes by conducting systematic reviews up to 31 May 2022, employing a meta-analytic method that incorporates between-study heterogeneity into estimates of uncertainty. Among the 36 selected outcomes, 8 had strong-to-very-strong evidence of an association with smoking, 21 had weak-to-moderate evidence of association and 7 had no evidence of association. By overcoming many of the limitations of traditional meta-analyses, our approach provides comprehensive, up-to-date and easy-to-use estimates of the evidence on the health effects of smoking. These estimates provide important information for tobacco control advocates, policymakers, researchers, physicians, smokers, and the public.
Kelly Compton, Rixing Xu, Lisa Force, Alistair Acheson, Dan Lu, Lindsey Wallace, Jonathan Kocarnik, Weijia Fu, Frances Dean, Alyssa Pennini, Hannah Henrikson, Tahiya Alam, Aleksandr Aravkin, Eunice Chung, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Mohammed Hassen, Simon Hay, Stephen Lim, Tomislav Mestrovic, Ali Mokdad, Christopher J.L. Murray, Hasan Nassereldine