Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000–17: a spatial and temporal modelling study

Published June 19, 2019, in The Lancet (opens in a new window)


Since 2000, the scale-up of malaria control interventions has substantially reduced morbidity and mortality caused by the disease globally, fuelling bold aims for disease elimination. In tandem with increased availability of geospatially resolved data, malaria control programs increasingly use high-resolution maps to characterize spatially heterogeneous patterns of disease risk and thus efficiently target areas of high burden.


We updated and refined the Plasmodium falciparum parasite rate and clinical incidence models for sub-Saharan Africa, which rely on cross-sectional survey data for parasite rate and intervention coverage. For malaria-endemic countries outside of sub-Saharan Africa, we produced estimates of parasite rate and incidence by applying an ecological downscaling approach to malaria incidence data acquired via routine surveillance. Mortality estimates were derived by linking incidence to systematically derived vital registration and verbal autopsy data. Informed by high-resolution covariate surfaces, we estimated P. falciparum parasite rate, clinical incidence, and mortality at national, subnational, and 5 × 5 km pixel scales with corresponding uncertainty metrics.


We present the first global, high-resolution map of P. falciparum malaria mortality and the first global prevalence and incidence maps since 2010. These results are combined with those for Plasmodium vivax (published separately) to form the malaria estimates for the Global Burden of Disease 2017 study. The P. falciparum estimates span the period 2000–2017, and illustrate the rapid decline in burden between 2005 and 2017, with incidence declining by 27.9% and mortality declining by 42.5%. Despite a growing population in endemic regions, P. falciparum cases declined between 2005 and 2017, from 232.3 million (95% uncertainty interval 198.8–277.7) to 193.9 million (156.6–240.2) and deaths declined from 925,800 (596,900–1,341,100) to 618,700 (368,600–952,200). Despite the declines in burden, 90.1% of people within sub-Saharan Africa continue to reside in endemic areas, and this region accounted for 79.4% of cases and 87.6% of deaths in 2017.


High-resolution maps of P. falciparum provide a contemporary resource for informing global policy and malaria control planning, program implementation, and monitoring initiatives. Amid progress in reducing global malaria burden, areas where incidence trends have plateaued or increased in the past five years underscore the fragility of hard-won gains against malaria. Efforts towards elimination should be strengthened in such areas, and those where burden remained high throughout the study period.

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Weiss DJ, Lucas TCD, Nguyen M, et al. Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000–17: a spatial and temporal modelling study. The Lancet. 19 June 2019. doi:10.1016/S0140-6736(19)31097-9.


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